Positive inotropic action and arrhythmogenic activity of denopamine (TA-064)
نویسندگان
چکیده
منابع مشابه
Cardiovascular effects and plasma levels of denopamine (TA-064), a new positive inotropic agent, in chronically instrumented dogs.
Cardiovascular effects of denopamine (TA-064), a new positive inotropic agent, in chronically instrumented dogs were investigated following intravenous and oral administration. In the conscious state, denopamine (0.5-4 micrograms/kg/min, i.v. infusion) increased LV dp/dtmax, cardiac output, stroke volume in a dose-dependent manner, and it decreased left ventricular end-diastolic pressure, total...
متن کاملContraction dependency of the positive inotropic action of cardiac glycosides.
The concept that the positive inotropic effect of cardiac glycosides is dependent on the contractile state of the myocardium was tested. Isolated left atria of rabbits, when driven electrically at 15, 30, 60 and 120/min (at 30, 33, or 37°C), responded to ouabain (1 yug/ml) in proportion to the number of contractions and not to the time of exposure or frequency of drive. Contraction-related effe...
متن کاملPositive inotropic action of insulin on piglet heart.
This study was designed to investigate changes in cardiac performance during hypoglycemia produced by the administration of insulin in the newborn piglet. With heart rate, aortic pressure, and aortic flow held constant, the treated group demonstrated a pronounced positive inotropic response manifested by an increase of dP/dt max to 138% of control values. Central nervous system function and bet...
متن کاملThe positive inotropic action of insulin in the canine heart.
ILl(. 1 U( '( ' I I1-SI. M. MI-I) INA and I'.J. KNII . I ' I N. 17~(' i>~sitiru il~o/r~l)ic acti~n ~t m~tdiu m the cmtiuc heart. I 'ur(q)can J. Pharmac,,~l. 18 {19721 107 115. 111C cflccl~; ol ghtcagon-l(y', ~, illsulJn ".,',,.ere s lud ied ()11 CallJllc ls,nlalcd papillar ' , lllusclc,, incul;..lled in (hCllO',,~,clh Kollc ',,oltltJotl and in tilt" F, cntobarbi t , .d ; incxthet l /¢ t l d,.)g...
متن کاملInotropic action of hexamethonium.
The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63765-0